But these medications share a fundamental limitation: they suppress the immune system broadly rather than targeting the specific autoimmune pathways driving myelin destruction
However, GSH levels tend to decrease with aging and in various age-related neurodegenerative diseases, especially Alzheimers disease, the most prevalent form of dementia affecting the elderly 11,12,13
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Without direct tissue quantification, it is unknown if the CNS exposure was high, or if the large systemic dose simply compensated for low anatomical delivery efficiency across the nasal mucosa